Endocrine Abstracts

Controversy about the optimal dose of 131I in thyrotoxicosis is ongoing. High doses result in higher cure rates, but are associated with elevated risk of hypothyroidism and irradiation exposure. There is no consensus as to the optimum period of thionamide discontinuation prior to treatment, nor to its impact on the success of RAI.We retrospectively analysed 151 clinical records of patients with thyrotoxicosis due to Grave’s disease or tox...

Introduction: Long term treatment with corticosteroids has been widely used, due to the well documented immunosuppressive and anti-inflammatory activity. Corticosteroids are among the most widely prescribed drugs in oncology and post-transplant patients. However, long-term treatment with a dose of corticosteroids, which equals prednisolone 5mg/day for at least 4 weeks, is very likely to result in suppressed function of the hypothalamic pituitary adrenal (HPA) axis, a condition...

Serum androgen levels are commonly suppressed in patients with benign cortisol-secreting adrenocortical adenomas due to ACTH suppression. Associated androgen co-secretion usually indicates malignancy. Here, we present a case a very large benign androgen and cortisol-secreting adrenocortical neoplasm.Case: A 24-year-old female was referred with a 1-year history of secondary amenorrhea associated with hirsutism and acne. She reported irregular menstrual cy...

Objective: The project was designed to Assess And IMprove (AAIM) the practice of healthcare professionals (HCPs) around the corticosteroid sick-day rule, involved in caring for transplant and oncology patients requiring treatment with corticosteroids long-term.Introduction: Corticosteroids are widely prescribed drugs in oncology and post-transplant patients. Long-term treatment with corticosteroids dose, which equals pre...

Introduction: Laparoscopic unilateral adrenalectomy (UA) is a frequent approach in managing patients with structural and functional adrenal disorders. Suboptimal assessment post-operatively can result in multiple adverse consequences, including adrenal insufficiency. However, the optimal post-operative assessment and long-term effects on physical and mental health have not been sufficiently documented. This study aims to investigate the long-term effects of UA...

Introduction: Ectopic ACTH syndrome is rare but is frequently severe condition because of the intensity of the hypercortisolism that may be dissociated from the tumoral condition. It should often be considered as an endocrine emergency requiring an emergency response both in terms of diagnostic procedures and therapeutic interventions. Patient management is complex and necessitates dual skills, in the diagnosis and treatment (1). Etomidate, an imidazole-derivative anesthetic a...

A 30 year-old Caucasian male presented for a routine check-up. He was known to have abnormal thyroid function tests since the age of 23 years of unclear nature/aetiology. He reported occasional palpitations and anxiety. There were no other symptoms on systems’ review. He did not take regular medication, was an ex-smoker and consumed alcohol socially. His mother had hypothyroidism and his maternal aunt’s thyroid nodules. He was euthyroid. A palpable isthmic nodule &#7...

Background: Most cases of hypopituitarism are due to pituitary tumours or their treatment. Surgery is the treatment of choice in cases of pituitary adenomas which account for 90% of sellar and parsellar lesions. We present an unusual case of a non-adenomatous pituitary mass presenting with panhypopituitarism.Case: A 56-year-old male with background of sickle cell trait and hypertension presented with syncope, lethargy and nausea. He had an 18-month histo...

Background: Bariatric surgery (BS) is a well-documented treatment targeting weight loss excess. There is little evidence of the impact of BS on antenatal glycaemic control. We present three cases of pregnancy post-BS, who experienced various degrees of hypoglycaemia during gestation.Case presentations: Three women aged 25-, 26-, and 36-years-old, who were previously euglycaemic, presented to the joint antenatal clinic wi...

Background: Bariatric surgery (BS) is a well-documented treatment targeting weight loss excess. There is little evidence on the impact of BS on antenatal glycaemic control. We present four cases of pregnancy post-BS, reviewed in the joint antenatal clinic, who experienced various degrees of hypoglycaemia during pregnancy.Case presentations: Four pregnant women (cases A–D, aged 25–36-years-old, 3–8years pos...